Vasodilating effect of Hypericum revolutum (Vahl) (Clusiaceae) methanol extract in rats
5/31/2021
Purpose: To investigate the vasodilating effect of Hypericum revolutum Vahl (Clusiaceae) in rats.Methods: H. revolutum aerial parts were extracted with methanol. The total methanol extract was fractionated with chloroform to yield fraction I. The remaining aqueous solution was chromatographed on Diaion HP-20 using water, 50 % methanol, and methanol to yield three fractions (II- IV). Total methanol extract and fractions I-IV were applied to phenylephrine-pre-contracted (10 μM) rat aortic rings at doses of 1, 3, and 10 μg/mL. Subsequent decreases in aortic tension were recorded by an isometric force transducer to evaluate the vasodilation. Column chromatography was utilized to separate the active components of the bioactive fraction.
Other Researches
8/23/2021
Kirenol: A promising bioactive metabolite from siegesbeckia species: A detailed review
3/4/2021
Repurposing of Some Natural Product Isolates as SARS-COV-2 Main Protease Inhibitors via In Vitro Cell Free and Cell-Based Antiviral Assessments and Molecular Modeling Approaches
6/17/2021
Nitric-Oxide-Mediated Vasodilation of Bioactive Compounds Isolated from Hypericum revolutum in Rat Aorta
7/25/2021
Natural Products of the Fungal Genus Humicola: Diversity, Biological Activity, and Industrial Importance
5/24/2021
Jojoba oil: An updated comprehensive review on chemistry, pharmaceutical uses, and toxicity
